Activity 2: Animal models for patient profiling

Description/aim:

In different animal models we study the peripheral and central consequences of peripheral nerve lesions, and how the behavioral changes is correlated to the neurochemical and genetic findings. The resulting glial reactions and morphological changes, and changes in the NO systems, as signs of neurodegenerative elements of pain pathophysiology, are in main focus of the animal studies. The effects of different drugs in these models are evaluated.

We have possibilities to compare similar events in humans and animals in a translational manner. For instance, neuropathic pain behavior in mice is connected to polymorphism in MHC genes and we can study if this is the case also in humans by doing the same analysis in the DNA samples available in our biobank, from patients suffering from neuropathic pain after hernia surgery. In an opposite direction, the identification of gene variants or any other biomarker related to pain symptoms in human subjects will open for possibilities to study these biomarkers in experimental animal pain models.

Taken together, the animal models combined with peptidomic approaches will serve as an instrument to identify pain-related biomarkers to be screened in samples collected from human pain patients. Conversely, experimental animals may be used for studies of biomarkers already identified in human subjects.

 

 

 

 

Project leader:

 

 

 

Participants:

  • Anna Carlsson (UU)
  • Anne-Li Lind (UAS)
  • Torsten Gordh (UAS)
  • Mathias Hallberg (UU)
  • Hiroyuki Watanabe (UU)
  • Odd-Geir Berge (UAS)
  • Martin Schmelz (UAS)

 

 

 

PARTNERS
Uppsala Berzelii Technology Centre for Neurodiagnostics | Email info@berzelii.uu.se