OKTOBER 6, 2016

New publication on Berzelii research

Read the lastest publication from researchers within the Berzelii Centre working with a newly developed method capable of multiplexed analyses of N-glycan profiles of specific proteins.

"Particle-based N-linked glycan analysis of selected proteins from biological samples using nonglycosylated binders"

[download article] or
read on-line: http://authors.elsevier.com/sd/article/S0731708516307026
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SEPTEMBER 1, 2015 | Read full article

Developing international e-infrastructure

Berzelii researchers are part of an international consortia developing e-infrastructure for analysing medical metabolic phenotype data


PhenoMeNal is a 3-year EU Horizon 2020 project starting on September 1st 2015 and will develop a standardised e-infrastructure for analysing medical metabolic phenotype data. This comprises development of standards for data exchange, pipelines, computational frameworks and resources for the processing, analysis and information-mining of the massive amount of medical molecular phenotyping and genotyping data that will be generated by metabolomics applications now entering research and clinic. (Text from http://www.farmbio.uu.se/forskning/researchgroups/pb/PhenoMeNal/)

Read more about PhenoMeNal:

[in English]

[in Swedish]

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AUGUSTI 28, 2015 | Read full article


Clinical Analysis & Research Applying Mass spectrometry & Bioinformatics at Akademiska


In collaboration between Dept. Medical Sciences (Assoc. Prof. Kim Kultima/Prof. Mats Gustafsson) and the Section of Clinical Chemistry and Pharmacology, Uppsala University Hospital (Torbjörn Åkerfeldt, MD, Medical head) a top-of-the-line high-resolution mass spectrometry laboratory has been established for research purposes and for use in routine analyses of patient samples. […] The aim of this joint initiative is to perform world-class pre-clinical and clinical research targeting endogenous and exogenous molecules (proteins, peptides, hormones and drugs) with the overall goal to improve human health care and disease prevention. This aim also includes implementing state-of-the-art as well as novel mass spectrometry and bioinformatics based methods for use in routine clinical applications.


(full text see: http://www.medsci.uu.se/caramba?sharedId=452824)

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MAJ 23, 2015 | Read full article

New Doctors in Uppsala Berzelii Centre

We are proud to announce that two of our Berzelii PhD students successfully defended their theses during May 2015. Congratulations to:


Dr. Anna Jonsson: ” The Impact of the Neuropeptide Substance P (SP) Fragment SP1-7 on Chronic Neuropathic Pain”

[Abstract: A. Jonsson]




Dr. Camilla Russell: ”Development of Electrical Readouts for Amplified Single Molecule Detection”
[Abstract: C. Russell]


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OKTOBER 14, 2014 | Read full article

Berzelii researcher invited to the AAAS Annual Meeting

Uppsala Berzelii Centre will be represented at the AAAS Annual Meeting.

The AAAS Annual Meeting gathers thousands of leading scientists, engineers, educators, policymakers, and science journalists for discussions about recent developments in science and technology. Next year Uppsala’s research on chronic pain will be highlighted in a separate symposium.

The American Association for the Advancement of Science (AAAS) is an international non-profit organization dedicated to “advancing science for the benefit of all people”. The organization publishes three respected peer-reviewed journals, Science, Science Signaling and Science Translational Medicine.

But at the Annual Meeting the audience and focus is a little different. Policymakers attend to learn more about the latest research and journalists from all over the world are looking for the best and latest science news, making it the perfect arena for reaching these groups.

The meeting has a peer review process, where research quality, as well as “news value” is evaluated. It is now confirmed that the Uppsala University symposium “Chronic Pain – An Invisible Disease? Not anymore.” with Professor Torsten Gordh has been accepted for the next Annual Meeting in San Jose on the theme “Innovations, Information, and Imaging”.

The symposium will address the wide-spread condition of chronic pain and the fact that pain is still measured using subjective self-reporting. The symposium will provide new ways of understanding chronic pain, and show the possibilities in developing new diagnostic tools in the evaluation of chronic pain patients.

Torsten Gordh will present imaging studies using PET-CT-scanning that reveal specific patterns of peripheral muscle tissue uptake in sites corresponding to the pain experienced by the patients. He will be joined by Clas Linnman at Boston Children’s Hospital, Harvard Medical School (previously Uppsala University) and Teshamae Monteith, University of Miami, who will address other aspects of chronic pain and imaging.



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MARS 24, 2014 | Read full article

Chronic Pain Meeting in Oslo

The Scandinavian Association for the study of Pain welcomes you to the Annual SASP-meeting 2014 in Oslo, April 8-9. A PhD course on Chronic Pain research will also be given in conjunction with the meeting.

We welcome you all to a high class scientific meeting:

• of interest for all “pain professions”

• presenting frontlines in pain research and treatment

Please see attached documents [invitation] and [PhD course] and the SASP webpage (www.sasp.org) for more information.

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JANUARI 28, 2014 | Read full article

Using golden DNA strands in biosensors

Scientists at Uppsala Berzelii Centre for Neurodiagnostics and Science for Life Laboratory have developed a brand new concept for super sensitive diagnostics of different diseases.

In the upcoming issue of ACS Nano they present an electrical sensor that uses rolling circle amplification (RCA) of DNA to stretch across the gap between two electrodes, interact with metal nanoparticle seeds to generate an electrically conductive nanowire, and produce electrical signals upon detection of specific target DNA sequences.

Camilla Russell, PhD student at Uppsala Berzelii Centre for Neurodiagnostics at Uppsala University and the researcher who has carried out the work, sees great potential in the ‘golden strand’ method:

“It should be possible to build very simple test kits using this method, and one test kit can contain many separate sensors to trace a large number of different DNA molecules”, she says.

Read more in the ACS Nano journal and the article published on the Uppsala university webpage; using golden DNA..

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OKTOBER 29, 2013 | Read full article

Visualizing Pain processes by PET

Researchers at Uppsala University have been able to visualize chronic pain processes in patients suffering from tennis elbow using PET-scan technique [PLoS ONE 8(10)]

Vävnadsprocesser vid långvarig mjukdelssmärta som kronisk tennisarmbåge kan visualiseras med bilddiagnostisk metod. Det visar resultat från forskare vid Uppsala universitet. Smärtläkaren och forskaren Magnus Peterson presenterar en ny användning av positron-emissions-tomografi (PET) och en markör för signalreceptorn NK1 för att visualisera en fysiologisk process associerad till smärtan.[Läs hela artikeln från www.uu.se här].
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MAJ 16, 2013 | Read full article

Uppsala Berzelii Centre enters Stage 3

In 2013 Uppsala Berzelii Centre enters Stage 3 with continued funding from VINNOVA and VR.

In this coming 3-year period the Centre will continue its mission to provide a platform where patient needs and clinical research can merge with high technologies and industrial expertise in fruitful collaborations.
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NOVEMBER 15, 2012 | Read full article

Successful international evaluation of Stage 2.

In September, 2012 an international team met in Uppsala to evaluate our Berzelii Centre.

The generalist evaluators together with the expert evaluator addressed matters such as organisation and management, finance, interaction between industry partners and the university, and educational activities.
After giving very constructive and good recommendations, the evaluation team concluded ”..that the Centre is a growing and actively improving example of a Berzelii Centre with a very promising future.”
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AUGUSTI 17, 2012 | Read full article

First Professor in Clinical Pain Research

Berzelii researcher Torsten Gordh gets the first Swedish Professorship in clinical pain research.


Uppsala University is the first Swedish university to establish a professorship in clinical pain research. The newly appointed first holder of this position is MD Torsten Gordh, expert and thematic area leader in the Chronic Pain research of Uppsala Berzelii Centre.


[read more]

(Article at Uppsala University web, in Swedish).

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JUNI 8, 2012 | Read full article

International Scientific Advisory Board together in Uppsala

On the 16th of May 2012 Uppsala Berzelii Centre had the great pleasure to welcome our International SAB for an on-site visit in Uppsala.
Our international experts, Prof. Troels Staehelin Jensen (Clinical and Experimental Pain Research, Aarhus University, Denmark), Prof. Michael Snyder (Department of Genetics, Stanford University, CA, US) and Prof. Thomas A. Bayer (Molecular Psychiatry, University Medicine Göttingen, Germany) showed great interest in all our Centre activities and kindly shared their recommendations for our future progress.


Prof. T. Jensen, Prof. M. Snyder and Prof. TA. Bayer at Ångström lab. in Uppsala, 2012.

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MAJ 11, 2012 | Read full article

Berzelii lectures at Ångström Lab May 16

It is our great pleasure to invite you to three exciting lectures:

Time: Wednesday May 16 between 15.30 and 17.00
Place: Polhemsalen, Ångströmlab Uppsala


(Source: www.uni-goettingen.de)

Lecture #1

"N-truncated amyloid-beta oligomers as novel target for Alzheimer disease therapy"

Prof. Dr. Thomas A. Bayer.
Professor in Molecular Psychiatry at the University Medicine Göttingen, Department of Psychiatry. Coordinator of the European Commission funded International Alzheimer PhD School «Neurodegeneration in Alzheimer’s disease – mechanism, consequence and therapy» (NEURAD). [University of Goettingen]

(Source: http://pure.au.dk/portal/en/tsjensen@ki.au.dk)

Lecture #2

"Risk factors for the development of persistent pain"

Prof, MD, DMSc Troels Staehelin Jensen
Professor of Clinical and Experimental Pain Research at Aarhus University, Denmark. Director of the Danish Pain Research Center. [Danish Pain Research Centre]

(Source: http://snyderlab.stanford.edu)

Lecture #3

"Adventures in personal genomics and whole omics profiling"

Prof Michael Snyder
Professor and Chair of Genetics at the Department of Genetics, Stanford University, California. Director at Stanford Center for Genomics and Personalized Medicine. [Mike Snyder Lab website]

Welcome !

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APRIL 26, 2012 | Read full article

Berzelii Pain research in focus

Article on Berzelii Pain research in the Swedish magazine "Dagens Medicin".

Read the interviews were Prof. Torsten Gordh and PhD-student Anne-Li Lind describe the progress of Pain research (text in Swedish).


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APRIL 19, 2012 | Read full article

Berzelii Centre in New Horizons

Berzelii PhD student Anne-Li Lind on front page in the University magazine "New Horizons".

Uppsala Berzelii Centre is on the front cover of the University Magazine "new Horizons". Read the nice article about our PhD student Anne-Li Lind and her research in the field of chronic Pain.

[Link to New Horizons on-line].




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FEBRUARI 21, 2012 | Read full article

Optic innovation awarded

Researchers Fredrik Nikolajeff and Axel Lundvall awarded by vice-chancellor at Uppsala University for outstanding entrepreneurship and innovations.

They receive the Prize “hjärnäpplet” for the idea to produce three-dimensional images in thin plastic sheeting. Since the start of “Rolling optics” in 2005 they have built up one of Sweden's most promising high-tech companies with 15 employees and its own production.

[read more] - In Swedish only


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DECEMBER 21, 2011 | Read full article

Ulf Landegren awarded

Prof. Ulf Landegren, PI and researcher in Uppsala Berzelii Centre have received one of the largest awards at Uppsala University, “Björkenska priset” 2011.
Ulf Landegren is also one of the first researchers at the Medical Faculty in Uppsala to receive ERC Advanced Grants.

Both prizes rewards Prof. Landegren for his successful research in the field of molecular analysis of DNA and proteins. The “Björkenska priset” will be handed over at the conferment ceremony on January 28, 2012 in Uppsala, Sweden.

Read more:

The award Björkénska priset 2011 to Ulf Landegren [press release Uppsala University]

Ulf Landegren awarded an ERC Advanced Grant [press release Uppsala University]

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NOVEMBER 7, 2011 | Read full article

Jacob Berzelius Exhibition

An exhibition on the world-famous chemist Jacob Berzelius will open at The Observatory Museum, Stockholm in the International Year of Chemistry 2011.

The exhibition shows among other things the Swedish Royal Academy’s unique collection of 3,000 well-preserved objects, scientific publications and letters after Jacob Berzelius. This collection is a significant Swedish scientific heritage of great Chemistry Historical value.

Read more at the homepage of The Observatory museum:



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JUNI 19, 2011 | Read full article

Berzelii Scientific Advisory Board in Uppsala

Two of the members of our International Scientific Advisory Board, Professor William Maixner, Univ. of North Carolina and Prof. Dr. Thomas A. Bayer, University Medicine Göttingen visited Uppsala in May 2011.

Besides attending the conferences, “Frontiers in Pain Research” and “Neurodegenerative Disorders - Immunotherapy and Biomarkers” their stay included full lab tours and meetings with responsible project leaders in Uppsala Berzelii Centre.
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MAJ 27, 2011 | Read full article

Visualization of chronic pain

In a recent publication in the well known journal of PLos ONE, researchers from Uppsala University Hospital present a diagnostic tool to objectively visualize pain.

This study visualize inflammatory processes in the neck region after Whiplash Associated Disorder grade II, by means Positron Emission Tomography using the tracer 11C-D-deprenyl, a potential marker for inflammation.

- Patients with chronic neck pain after whiplash are often met with disbelief because nothing abnormal is showing in x-ray or MRI examinations. We can now show that it is possible to obtain objective visual evidence that the pain actually occurs in the neck, says Professor Torsten Gordh, head of the Pain Center at the University hospital.


[News article, UNT April 21, 2011]  (in Swedish).

[Article PLos ONE April 19 2011]


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MAJ 24, 2011 | Read full article

New findings from Berzelii researchers

Researchers from Uppsala University have discovered a new marker that gives hope for more reliable diagnosis of prostate cancer.

Uppsala Berzelii Centre researchers Masood Kamali-Moghaddam and Ulf Landegren have developed a new blood test which hopefully may provide more reliable diagnosis of prostate cancer.
- Our study is limited, but if we can show equally good results in large studies, we believe that our test can replace or supplement the PSA, says Masood Kamali-Moghaddam, whose study is recently published in the scientific journal Proceedings of the National Academy of Sciences, PNAS .


[News article, DN 2011-05-10]  (in Swedish)

[Article in PNAS, May 2011]



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OKTOBER 21, 2010 | Read full article

Prestigious prize to Berzelii researcher

Professor Lars Lannfelt at the Department of Public Health/Geriatrics at Uppsala University will receive a 2010 Alzheimer Research Forum Outstanding Contributor Award at the society of Neuroscience annual meeting in San Diego, Calif. November 2010.

The Alzforum Awards have become an annual ritual to recognize altruism among Alzheimer researchers. Every year, the editors consider the many scientists who have actively contributed to the Alzheimer Research Forum website and select a choice half-dozen who have gone to extra lengths to serve this Web community.
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SEPTEMBER 3, 2010 | Read full article

First clinical study started with Alzheimer drug

A novel antibody developed by BioArctic Neuroscience AB in Sweden will be studied in a clinical trial on more than 80 Alzheimer s patients with mild to moderate forms of the disease....

"BAN2401 is a novel antibody targeting the neurotoxin believed to cause Alzheimer s disease and developed by BioArctic Neuroscience..."

Read more on [www.bioarctic.se].


"Ny medicin prövas på Alzheimerpatienter

En ny typ av läkemedel mot Alzheimers sjukdom som utvecklats av forskare vid Uppsala universitet har nu för första gången börjat prövas på patienter...."
Läs mer [här] - artikel i UNT 2010-09-03,


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SEPTEMBER 1, 2010 | Read full article

FRONTIERS IN PAIN RESEARCH 19th - 21st May 2011 in Uppsala, Sweden

The Scandinavian Association for the Study of Pain in cooperation with Uppsala Berzelii Technology Centre for Neurodiagnostics welcomes you to The NewSASP Annual meeting in Uppsala, Sweden from 19th - 21st May 2011.


Main topics:

  • Biomarkers for understanding of pain pathophysiology and choice of treatment - a new field.
  • Imaging of painful processes in peripheral tissues using PET and fMRI - a new diagnostic tool?
  • Nurse lead interventions to improve pain treatment. Frontlines in research.
  • Transduction to sensation - Ion channel news!
  • The role of glial cells in the patophysiology of pain. Are they really relevant to pain in humans?
  • Biological agents (NGF-antibodies etc) in the treatment of pain - how effective are they? And in what pain states?

Key note speaker on "Biomarkers of pain": William Maixner, Professor, Chapel Hill, NC, USA.


We aim to create an arena with plenty of time for networking, interesting interactions between young researchers and established veterans, from basic and clinical pain research. Heartily welcome to Uppsala , the city of Carl von Linnaeus, in May - the beautiful month of the spring flowers!

Torsten Gordh, President of the newSASP, email: torsten.gordh@akademiska.se

For more information about registration, abstracts, hotel booking, etc., please go to www.sasp.org.

[1st announcement for download]

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JUNI 17, 2010 | Read full article

Uppsala Berzelii Centre partner rewarded

The newly started company Molecular Fingerprint Sweden AB will get 300 000 SEK from the VINN NU-programme funded by The Swedish Governmental Agency for Innovation Systems, VINNOVA and The Swedish Energy Agency.

Molecular Fingerprint Sweden AB will be rewarded for their research and development of diagnostic tools for i.e. Alzheimers disease and their advanced protein analyses.

- VINNOVA 2010-06-17 -

[read more, article in Swedish]

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JUNI 14, 2010 | Read full article

Groundbreaking news on human CSF proteins

For the first time, researchers from Sweden and the US have succeeded in identifying the majority of the detectable proteins in the cerebrospinal fluid (CSF) of healthy human beings. The advance is expected to provide a valuable tool for diagnosis and research into diseases of the nervous system. The study is being published today in the well-respected journal PLoS ONE.

Mapping the mix of 2,630 identified proteins in the CSF of healthy human beings may represent a turning point for research in neurological diseases. Until now, the lack of a clear picture of normal CSF made it impossible to fully assess how the fluid is affected by different disease conditions.

“Obtaining this tool represents a very important step,” says Jonas Bergquist, professor of analytic chemistry and neurochemistry at Uppsala University in Sweden and a researcher at the Uppsala Berzelii Technology Centre for Neurodiagnostics.“Our findings could serve as a representation of the normal case in connection with research into Alzheimer’s, ALS, Parkinson’s, multiple sclerosis and many other diseases.”

[read more]...

- www.uu.se / Press release published 2010-06-12 -

Read the article in PLoS ONE.

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JUNI 3, 2010 | Read full article

Cross-disciplinary research on nerve system at Uppsala

Dementia and chronic pain are two pathological conditions that are on the rise in society, which increases the need for better diagnosis and treatment. Within the framework of the Uppsala Berzelli Center, which has been in existence since 2007, both clinical and basic research in the field has made great forward strides. On June 8 there will be an open seminar on the present state of research and the future.

What is happening on the research front in the fields of pain and Alzheimer’s disease? What commitments are being made by society and companies in these fields in the near future? On June 8, research leaders, ministry representatives, and business people will gather for an open seminar about the two tremendously exciting research fields. Researchers will give a progress report on their work, senior administrative officers Maria Wästfelt and Lotta Liljelund from the ministry of education and research will speak about health-care initiatives, and representatives from AstraZeneca and GE Healthcare will present what the business community can contribute.

Apace with advances in our knowledge of the genetics and molecular processes behind various pain conditions and dementia disorders, new opportunities are opening up for diagnosis and treatment. The encounter with patients at the clinic also often leads to questions for which there has been no technology in place to provide the answer. This is where the Uppsala Berzelii Center comes in. Torsten Gordh, a pain researcher at Uppsala University and chief physician at the Pain Clinic, Uppsala University Hospital, says the center is a fantastic resource.

“Through collaboration between basic researchers and companies we have gained access to entirely new methods involving biomarkers that can be used on biobank materials from well-characterized pain patients. This is something completely new and has led to a great deal of new knowledge that can benefit patients,” he says.

Both Alzheimer’s and pain research at Uppsala University is of top international quality, and University Hospital is clinically prominent. The areas are also interesting to Uppsala’s life-science companies. At Uppsala Berzelli Center there is now very active collaboration between these parties, firmly anchored in clinical needs and in the University’s advanced competence in chemistry and molecular method development. The goal is to pilot ideas from basic research to commercial products for clinical use.

“With access to patient materials, the robust development of technology, and the expertise of companies, we are uniquely positioned to succeed,” says Fredrik Nikolajeff, director of the Uppsala Berzelii Center.


[news, Uppsala University, www.uu.se]

Anneli Waara


Editor: Anneli Waara | Webmaster | Updated: 2010-06-03 17:44

©-2006. UPPSALA UNIVERSITET, Box 256, 751 05 Uppsala

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MAJ 15, 2010 | Read full article

Science for Life Laboratory

SciLifeLab is a joint collaboration between Stockholm and Uppsala dedicated to large scale research in molecular biosciences and medicine...

"Science for Life Laboratory (SciLifeLab) is a national resource center dedicated to large scale research in molecular biosciences and medicine. The major funding for SciLifeLab comes from strategics grants from the Swedish government.

The organisation is divided in two parts, SciLifeLab Stockholm and SciLifeLab Uppsala. SciLifeLab Stockholm is a joint collaboration between three universities, The Royal Institute of Technology (KTH), Karolinska Institute (KI) and Stockholm university (SU). SciLifeLab Uppsala is organised by Uppsala University (UU).

The two sites are collaborating with an increasing intensity on a strategic as well as on a practical level..."

[from the webpage SciLifeLab.se]

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MAJ 11, 2010 | Read full article

Uppsala Berzelii Centre Symposium - UBS 2010

An open seminar about Chronic Pain- and Alzheimer's Disease research will be arranged by Uppsala Berzelii Centre the 8:th of June in Uppsala...

(The seminar will be in Swedish)


Den 8 Juni öppnar Uppsala Berzelii Centre dörrarna och inbjuder till ett symposium kring forskning om Alzheimers sjukdom och kronisk smärta...

[läs hela programmet här]

Uppsala Berzelii Technology Centre for Neurodiagnostics är en 10-årig centrumsatsning med fokus på excellent grundforskning i nära samarbete med näringslivet. Denna unika sammansättning av forskare från Uppsala universitet, Uppsala Akademiska sjukhus och industrin arbetar idag gemensamt mot målen att hitta biologiska markörer för tidig diagnostik samt öka våra kunskaper om Alzheimers sjukdom och kronisk smärta.

Områden som kommer presenteras vid seminariet:

  • Var står vi idag i forskningen kring Alzheimers sjukdom?
  • Har vi verktygen att mäta kronisk smärta?
  • Hur kan vår forskning hjälpa patienterna?
  • Hur kommer Sverige satsa på dessa sjukdomsområden?

Missa inte detta unika tillfälle att lära dig mer om framtidens diagnostik och läkemedel.


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DECEMBER 1, 2009 | Read full article

Swedish network for biobanking

BBMRI will make Sweden an international leader in biobanking...

A new research collaboration with funding from the Swedish Research Council have been established to unify Swedish infrastructure for biobanking...

[read more at BBMRI.se]

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JUNI 27, 2007 | Read full article

På jakt efter nya biomarkörer

Med hjälp av känsliga analysmetoder hoppas Uppsala Berzelii Technology Center for Neurodiagnostics att inom tio år hitta biomarkörer i människokroppen som visar när en neurodegenerativ sjukdom som Alzheimers sjukdom eller ALS håller på att utvecklas.

- VINNOVA-nytt: #3.07 -

[Läs artikeln]

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JUNI 27, 2007 | Read full article

Nytt Centre för Neurodiagnostik i Uppsala

Känsligare analysmetoder som kan avslöja sjukdomar som Alzheimer och Parkinson i ett tidigt skede. Det är ett av målen för det nystartade Uppsala Berzelii Technology Center for Neurodiagnostics. Centret ska också öka våra kunskaper om kronisk smärta.

Fredrik Nikolajeff vill gärna se forskningsresultat omsättas i praktiken. Som när rymdbolaget ESA hörde av sig efter att han och en kollega publicerat nya rön om hur konstgjorda diamantytor kan mikrostruktureras.

- ESA frågade om vi kunde tillverka skräddarsydda optiska mikrostrukturer i diamantfönster för framtidens satelliter. Detta ledde till att vi startade ett företag runt vår teknik. Han ser händelsen som ett exempel på fördelarna med att göra något unikt.

- Då hör andra av sig och vill börja samarbeta säger Fredrik Nikolajeff, som menar att Sverige som forskningsnation bör ha samma strategi. Att följa strömmen och ligga i forskningens huvudfåra gör det allt svårare att konkurrera när låglöneländer som t ex Kina satsar stort.

[Läs hela artikeln från Vetenskapsrådet]

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JANUARI 1, 2007 | Read full article

Research awarded a 10-year grant

The Uppsala Berzelii Technology Center for Neurodiagnostics was awarded a 10-year grant from the Swedish Research Council and the Swedish Agency for Innovation Systems, in order to establish a multidisciplinary center targeting neurodegenerative diseases.

- BIOforum Europe 12/2006 -
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Uppsala Berzelii Technology Centre for Neurodiagnostics | Email info@berzelii.uu.se