Uppsala University Hospital is the oldest and one of the largest university hospitals in Sweden. It is the hospital in Sweden with the highest percentage of highly specialized tertiary care.

Four clinical departments are currently active in the Centre:

 

Dept of Clinical Chemistry and Pharmacology

Research head: Prof Anders Larsson

The department has 140 employees (7 professors, 16 MDs) with a turnover of approx 100 MSEK in 2005 and is responsible for centralized and point-of-care testing in Uppsala County. It produces 5 million assays and 1.5 million point-of-care tests per year, and has a broad repertoire of immunoassay instruments. During 2005 the laboratory evaluated and introduced more than 100 new assays (primarily immunological assays). The laboratory is accreditated by Swedac and participates in several external quality assurance programs. The laboratory has an excellent access to patient materials, and is presently involved in several of the large cohort studies in Sweden (e.g. Monica, Pivus and Ulsam).


The department will contribute with clinical patient materials, antibodies and antibody production. The laboratory will also perform the clinical evaluations of the human tests and will contribute with expertise in clinical testing.


Dept of Surgical Sciences/Multidisciplinary Pain Clinic

Research head: Prof Torsten Gordh

The group is focusing on the understanding of chronic pain. In some respects, the causes of chronic pain may be regarded as a state of neurodegeneration in the peripheral and central nervous system. To explore the research, experimental (animal- and human models) and clinical studies on genetics, molecular mechanisms, biological markers, clinical findings, patient related outcome, and epidemiology are carried out. The aim is to provide a deeper knowledge in order to develop new tools for treatment and prophylaxis.


The department will contribute with patient samples from the multidisciplinary pain clinic and be a link to national research groups within the Uppsala Pain Network and international collaborations.

 

Dept of Neurosurgery

Research head: Prof Lars Hillered

The research of the group is focusing on the metabolomics and proteomics of Traumatic Brain Injury (TBI) and Subarachnoid Hemorrhage (SAB) using cerebral microdialysis, introduced by us as a sampling tool in Neurointensive Care in 1992. The group studies neurochemical mechanisms of secondary injury following TBI and SAH and thrive at finding new biomarkers with diagnostic and prognostic clinical value. The research is a major part of a multidisciplinary research network, the Uppsala Brain Injury Centre (UBIC). The overall goal is to combat TBI from molecule to man in a translational endeavor involving molecular genetics, animal models, stem cell transplantation, tissue engineering, neurointensice care and neurorehabilitation.


The department will contribute with patient materials and experience in projects relating to sample taking, specifically microdialysis.

 

Dept of Public Health/Geriatrics

Research head: Prof Lars Lannfelt

The unit is focusing on two areas of research: i) Molecular studies of dementia at the Rudbeck Laboratory. The research is divided in four groups, transgenic animal models, immunoassays, functional genetics and genetics. ii) Clinical and epidemiological research in these disorders. The group is using cellular- and transgenic mice models of Alzheimer’s disease to better understand mechanisms of amyloid formation in the brain, and to develop disease modifying therapeutics. The group has also developed monoclonal antibodies specifically recognising amyloid beta protofibrils.


The department will contribute with biological tissue such as brain, CSF, plasma and fibroblasts from Alzheimer patients which will be evaluated for amyloid beta protofibril content. New findings might be extended into methods for early diagnosis of Alzheimer’s disease and as a biomarker to follow amyloid-directed therapies.

 

PARTNERS
Uppsala Berzelii Technology Centre for Neurodiagnostics | Email info@berzelii.uu.se