Eight academic research groups at Uppsala University, representing six different departments, are currently active in the Centre:


Dept of Engineering Sciences

Research group head: Assoc Prof Fredrik Nikolajeff

The group is using microfabrication and nanotechnology for development of microfluidic components and systems. Advanced processes and cleanroom equipment, such as lithography and plasma etching, for working with a range of materials are available. The group is currently focusing on the interaction between larger biomolecules and carbon based materials for protein analysis.

The group will develop a novel microfluidics based protein analysis method using mid-IR spectroscopy, relevant for biomarker identification in both Alzheimer’s disease and chronic pain.

 

Dept of Engineering Sciences

Research group head: Prof Klas Hjort

The group has for the last five years put a focus on microsystems in thin polymer-based circuitboards, stainless steel, and elastomers. Applications are in bioMEMS and wireless sensor networks. The group has unique competence in ion track lithography for nanowires and pores in polymer foils.

The group will focus on sampling of larger biomolecular markers by improving current microdialysis methods, which can be used for in-vivo analyses of traumatic brain injury, Alzheimer’s disease or chronic pain patients.

 

Dept of Physical and Analytical Chemistry

Research group head: Prof Jonas Bergquist

The group has a long experience in proteomics and access to a large number of mass spectrometry instruments with high sensitivity, resolution and accuracy well suited for performing analysis of candidate biomarkers. The group is also developing improved instrumentation and processes for performing these analyses.

The group will contribute with mass spectrometry equipment for sensitive analysis and screening of potential biomarkers in body fluids (CSF, blood, urine) from patients and animal tissue.

 

Dept of Biochemistry and Organic Chemistry

Research group head: Prof Lars Baltzer

The quality and resolution of all results in proteomics research depend ultimately on the selectivity and affinity of the molecules used to recognize and bind biomarkers in biological samples. The group develops a new type of molecules for protein recognition, which are polypeptides conjugated to small organic molecules or peptides, that offers several advantages over conventional technologies.

The group will develop new binders for a number of potential protein biomarkers which will aid the discovery and validation phases in both Alzheimer’s disease and chronic pain.

 

Dept of Pharmaceutical Biosciences

Research group head: Prof Fred Nyberg

The group directs studies on neuropeptides, neurohormones and steroids in relation to chronic pain and drug dependence (including experimental animal models, in vitro cell cultures, analytical biochemical techniques, gene typing and in collaboration clinical studies). The group also studies the functions of growth hormone and prolactin and their receptors in the central nervous system.

The group will contribute with animal studies, relevant for chronic pain projects.


Dept of Public Health and Caring Sciences/Geriatrics

Research group head: Prof Lars Lannfelt

The major research focus of the dementia research group is to establish better diagnostic methods for Alzheimer’s disease and to develop new immunotherapeutic strategies. The research group is using cellular and transgenic models of Alzheimer’s disease to better understand mechanisms of the disease. A broad repertoire of experimental approaches is being used, such as molecular biology, biochemistry, histology and behavioural analyses.

The group will contribute with samples from their tissue bank and with antibodies, transgenic mouse model for Alzheimer’s disease as well as importantly clinical and biochemical knowledge of neurodegenerative diseases in general.

 

Dept of Genetics and Pathology

Research group head: Prof Ulf Landegren

The group has pioneered high-throughput genotyping methodology, but in recent years the interest has gradually shifted towards protein analyses. The group has a relatively broad range of competences, including chemical synthesis, biochemistry, molecular biology, and microfabrication. The proximity ligation mechanism, developed in our lab, can enable extremely sensitive and specific detection of proteins of diagnostic interest.

The group will contribute with new sensitive technologies for pharmaceutical studies and biomarkers for Alzheimer’s disease and chronic pain.

 

Dept of Genetics and Pathology

Research group head: Prof Mats Nilsson

The research is focused on developing single-molecule and single-cell gene analytic tools, employing advanced molecular tools combined with microscopy and microfluidics. The research is cross-disciplinary and involves collaborations with research groups in clinical disciplines as well as engineering. The laboratory is equipped with advanced microscopy and molecular biology analysis instruments.

The group will contribute with new methods for rapid miniaturized diagnostic tests, which eventually can be used for early diagnosis of Alzheimer’s disease or chronic pain.

 

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Uppsala Berzelii Technology Centre for Neurodiagnostics | Email info@berzelii.uu.se